Incidence and genetics of Legg-Perthes disease (osteochondritis deformans) in British Columbia: evidence of polygenic determination.

نویسندگان

  • I M Gray
  • R B Lowry
  • D H Renwick
چکیده

Legg-Perthes disease (osteochondritis deformans) is an aseptic necrosis of the capital femoral epiphysis. The clinical and radiographic features of Legg-Perthes disease have been well documented (Goff, Shutkin, and Hersey, 1954; Kemp and Boldero, 1966) but apart from Molloy and MacMahon's Massachusetts study (1966) few epidemiologic investigations have been reported. A genetic component to the disease has been suggested by many authors (Goff et al, 1954; Goff, 1962) but the extent of familial occurrence and mode of inheritance have not been defined. The objectives of this study were twofold: firstly, to determine the incidence of Legg-Perthes in the Province of British Columbia, Canada, by identifying all children in whom the diagnosis was made for the first time during the period 1952-67 inclusive; secondly, to analyse for possible genetic factors.

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عنوان ژورنال:
  • Journal of medical genetics

دوره 9 2  شماره 

صفحات  -

تاریخ انتشار 1972